Pre-Test 1. All of the following are true about the spleen except: a. Reticulin fibers fill the stroma of the spleen b. White pulp provides a location for B cells to proliferate and differentiate c. In open circulation, penicillar arterioles dump blood directly into splenic cords d. Stave cells present antigens to B lymphocytes in white pulp forming lymphoid nodules e. T cells surround arterioles in the spleen, known as periarteriole lymphatic sheaths (PALS) 2. During an infection, why do lymph nodes increase in size? a. B cell proliferation forming lymphoid nodules (follicles) in the medulla b. Enlargement of the subcapsular sinus with plasma cells c. Congestion of the medullary sinuses with antigen presenting cells (APCs) d. Clonal proliferation of T cells in the cortex e. Antigen presentation by follicular dendritic cells to B cells in the cortex 3. An embryologic malformation in the 3rd pharyngeal (branchial) pouch results in decreased differentiation of thymic epithelial cells (TECs) leading to thymic hypoplasia. What pathology would you expect from this smaller thymus? a. Decreased antigen-presentation to developing thymocytes in the medulla (positive selection) and the x (negative selection) b. Increased tight barriers between peripheral blood and the thymic stroma c. Failure of thymic (Hassall's) corpuscles to form leading to decreased cytokine production for T cell development d. An abundance of T-lymphocytes leading to overactive adaptive immune responses and autoimmunity e. Both A and C are possibilities 4. Which of the following is true regarding M cells? a. They function to increase efficiency of lymphoid nodule activity in the appendix b. They concentrate antigens, dendritic cells, and lymphocytes in intracellular pockets c. They produce IgA mediating inflammatory reactions for defense of the mucosal surface d. They produce hormones and other signaling molecules in response to antigen presentation in primary lymphoid organs e. They are synonymous with enterocytes 5. Name the cell at the arrow tip. a. Lymphocyte b. Monocyte c. Basophilic erythroblast (N1) d. Neutrophil e. Metamyelocyte Submit